DEVELOPMENT OF DUAL-TARGETED MIXED MICELLES LOADED WITH CELASTROL AND EVALUATION ON TRIPLE-NEGATIVE BREAST CANCER THERAPY

Development of Dual-Targeted Mixed Micelles Loaded with Celastrol and Evaluation on Triple-Negative Breast Cancer Therapy

Considering that the precise delivery of Celastrol (Cst) into mitochondria to induce mitochondrial dysfunction may be a potential approach to improve the therapeutic outcomes of Cst on TNBC, a novel tumor mitochondria dual-targeted mixed-micelle nano-system was fabricated via self-synthesized triphenylphosphonium-modified cholesterol (TPP-Chol) and

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Tobacco and alcohol use are the risk factors responsible for the greatest burden of head and neck cancers: a study from the Global Burden of Disease Study 2019

Background The risk factors associated with cancers of the larynx, nasopharynx, lips, and oral cavity, as well as other pharyngeal cancers, share many similarities.To better understand how these risk factors manifest differently across various head and neck tumor types, we utilized data from the GBD database to conduct an in-depth analysis.Methods

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The effect of laser welding parameters on mechanical properties and microstructure evolution of multi-layered 6061 aluminum alloy

In this study, the key findings of evaluating laser beam welding parameters on the multi-layered structure of 6061 aluminum alloys fabricating by accumulative roll bonding process are reported, considering fostering mechanical properties concerning the influence of filler metal and welding speed on the weld bead quality by taking into account reduc

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